I use Norman layout on my ErgoDox.
David (the layout's author) claims it's 46% less effort than QWERTY and I tend to agree. I'm still fluent in QWERTY on regular keyboards, to reach my full speed takes a couple of minutes.
Comparison of Norman layout with QWERTY
Note for Vim/vi users: I don't remap any keys and HJKL works just fine for me.
P.S. I still use QWERTY on regular keyboards.